Working with people who live with infectious diseases such as HIV/AIDS, Hepatitis C, Tuberculosis or are affected by a current pandemic situation of SARS-CoV-2 requires a well-equipped ‘toolbox’ of skills and knowledge, multiple levels of action: direct practice with specific, vulnerable target groups, individual casework, and social group work. In the face of rapidly changing pandemic situation, responsive and adaptive social work practice is especially important in relation to sustainable development goals.